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Plecasoft contains the active ingredient plecanatide, which works directly in the intestine to help increase fluid and support regular bowel movements. It acts like a natural substance in your body to draw water into the intestines, making stools softer and easier to pass. This makes stools softer and easier to pass. It helps relieve symptoms like hard stools, bloating, and stomach discomfort. Plecasoft is used in adults to treat long-term(chronic) constipation and constipation caused by irritable bowel syndrome (IBS-C).