Association of Colon and Rectal Surgeons of India
AFCP (Association of Colon and Rectal Surgeons of India) presented the Platinum Sponsor Award to Mr. P K Guha.
Post marketing assessment of the efficacy and safety of S(-) Amlodipine
Abstract
Aim: This is a post marketing surveillance carried out to assess the clinical safety and efficacy of S(-) Amlodipine in patients with hypertension.
Materials & Methods: 81 practicing physicians throughout India collaborated in the recruitment of 235 hypertensive patients over a period of 6 months. Hypertensive patients were administered S(-) Amlodipine (2.5 or 5 mg). The fall in Blood pressure was observed at the end of 30 days. Serious adverse events were also reviewed.
Results: Significant reduction was observed in the systolic and diastolic blood pressure after treatment with S(-) Amlodipine for a period of 30 days. More than 80% of the patients on S(-) Amlodipine monotherapy achieved the JNC 7 goal in standing, sitting and supine positions.
Conclusion: These results are reassuring and provide further evidence of the safety and efficacy of S(-) Amlodipine in the management of hypertension.
Citation
Dewan B, Philipose N. Post-marketing assessment of the efficacy and safety of S (-) Amlodipine. Medicine Update. 2009;17(4):21-25.
Clinical efficacy and safety of Netilmicin in the Indian population: Practitioner's perspective
ABSTRACT
Aim: To determine the Indian Practitioner's Perspective on the clinical efficacy and safety of Netilmicin (NETROMAX)
Materials & Methods: 105 practitioners, including surgeons, chest specialists, pediatricians and internal medicine specialists, throughout India collaborated in the recruitment of 202 patients over a period of 6 months. Patients with bacterial infections were administered Netilmicin (NETROMAX) as determined by the practitioner, and the practitioner's opinion on the clinical efficacy and safety were observed at the end of treatment duration.
Results: 161 patients were evaluable for efficacy of Netilmicin (NETROMAX). The most commonly employed regimen by the practitioners was administrating 300 mg Netilmicin (NETROMAX) I.V. once daily for up to 14 days. Favorable clinical response, as correlated with the practitioner's opinion, was observed in 94.4% of the patients. The opinion that Netilmicin (NETROMAX) provided excellent therapeutic, rather than only prophylactic, benefits to the infected patients was given by 57.55% of the practitioners. Netilmicin (NETROMAX) was well tolerated in the evaluable patients with only two patients (1%) complaining of adverse events.
Conclusion: Netilmicin (NETROMAX) was found to be a safe, well tolerated and useful aminoglycoside to treat a number of bacterial infections in current Indian scenario.
Citation
Update citation as Dewan B, Balasubramanian A. Clinical efficacy and safety of Netilmicin in the Indian population: Practitioner’s perspective. Medicine Update. 2009;17(8);29-33
Evaluation of The Efficacy and Safety of Zostum (Combination of Cefoperazone and Sulbactam) followed by Zostum-O (Cefditoren) in Prevention of Surgical Infections
Abstract
Aim : The purpose of the present study was to assess the efficacy of an empiric peri-operative prophylactic regimen in prevention of surgical site infections (SSI), using cefoperazone & sulbactam combination to be followed by oral switch over therapy with cefditoren.
Material and Methods: It was an open, non comparative, multicentric, post-marketing surveillance study of 190 patients from 95 surgical centers, spread across India, undergoing various types of emergency and elective surgeries. Patients were categorized according to the type of operative wound as "clean", "clean contaminated", "contaminated" and "dirty". They were evaluated according to the Southampton scoring system.
Result: The rate of SSI in general was 7.36%. The observed rate of SSI for patients with dirty wounds was 3.92% whereas it was 3.07%, 6.38% and 25.9% for clean, clean contaminated and contaminated wounds respectively. The global wound score got reduced from 12.89 on day 1 to 2.75 on day 8 (p<0.01).
Conclusion: This is the first study clearly providing the efficacy data to reduce the incidence of SSI with the peri-operative antibiotic regimen of `Zostum', consisting of cefoperazone & Sulbactam for an average duration of 5 days followed by switch over to oral antibiotic prophylaxis with `Zostum 0', containing cefditoren. The result of the present study shows a superior outcome as compared to earlier studies in peri-operative prophylaxis conducted with single cephalosporins. In conclusion, this regimen is highly effective and can be adapted for wide varieties of surgeries.
Citation
Dewan B, Savarkar S. Evaluation of the Efficacy and Safety of Zostum (Combination of Cefoperazone and Sulbactum) followed by Zostum-O (Cefditoren) in Prevention of Surgical Infections. Indian Medical Gazette. 2009; CXLIII(7):249-256.